Which pharmacological principle explains why repeated drug administration can lead to decreased effect?

A Synergism

B Tolerance — reduced responsiveness to a drug after repeated exposure requiring higher doses

C Potentiation

D Bioavailability

✓ Correct Answer: Option B

Tolerance: diminished pharmacological response to a drug with repeated use. Pharmacokinetic (increased metabolism) or pharmacodynamic (receptor downregulation). Tachyphylaxis: rapid tolerance development.

💡 Why is B) the correct answer?

The correct answer to the question "Which pharmacological principle explains why repeated drug administration can lead to decreased effect?" is Option B: Tolerance — reduced responsiveness to a drug after repeated exposure requiring higher doses.

The other options — A) Synergism, C) Potentiation, D) Bioavailability — are incorrect for this Everyday Science question. As explained above: Tolerance: diminished pharmacological response to a drug with repeated use. Pharmacokinetic (increased metabolism) or pharmacodynamic (receptor downregulation). Tachyphylaxis: rapid tolerance develop…

📚 About This Everyday Science Practice Question

This 2-level Everyday Science question from the Human Body & Biology topic is part of One Paper Preparation's free exam preparation library. Each question includes the correct answer and a detailed explanation to help you understand the underlying concept, not just memorize the answer.

How to use this page: Read the question above, consider all four options (A through D), then check the highlighted correct answer and explanation. For active timed practice, start a free Everyday Science practice test or use flashcards for spaced repetition review.

Practice Everyday Science Quizzes → Browse All Questions Study Flashcards

Which pharmacological principle explains why repeated drug administration can lead to decreased effect?

✓ Correct Answer: Option B

📚 About This Everyday Science Practice Question

Related Everyday Science Questions