Category: Everyday Science | Last updated: 2026-09-18
Which pharmacological principle explains why repeated drug administration can lead to decreased effect?
A) Synergism
B) Tolerance — reduced responsiveness to a drug after repeated exposure requiring higher doses
C) Potentiation
D) Bioavailability
Explanation
Tolerance: diminished pharmacological response to a drug with repeated use. Pharmacokinetic (increased metabolism) or pharmacodynamic (receptor downregulation). Tachyphylaxis: rapid tolerance development.