Type 1 diabetes mellitus is primarily caused by:

A) Insulin resistance

B) Autoimmune destruction of pancreatic beta cells leading to absolute insulin deficiency

C) Excess insulin production

D) High sugar diet

Explanation

Type 1 DM: T-cell mediated autoimmune destruction of beta cells. Leads to absolute insulin deficiency. Presents in childhood/adolescence. Associated with HLA-DR3/DR4. Requires insulin therapy.

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