The p53 tumor suppressor gene is known as the guardian of the genome because it:

A Promotes cell division

B Arrests the cell cycle or induces apoptosis in cells with DNA damage

C Replicates DNA

D Only affects liver cells

✓ Correct Answer: Option B

p53: activated by DNA damage → upregulates p21 (CDK inhibitor) → G1 arrest. If damage irreparable, triggers apoptosis. Mutated in >50% of human cancers.

💡 Why is B) the correct answer?

The correct answer to the question "The p53 tumor suppressor gene is known as the guardian of the genome because it:" is Option B: Arrests the cell cycle or induces apoptosis in cells with DNA damage.

The other options — A) Promotes cell division, C) Replicates DNA, D) Only affects liver cells — are incorrect for this Everyday Science question. As explained above: p53: activated by DNA damage → upregulates p21 (CDK inhibitor) → G1 arrest. If damage irreparable, triggers apoptosis. Mutated in >50% of human cancers.

📚 About This Everyday Science Practice Question

This 3-level Everyday Science question from the Human Body & Biology topic is part of One Paper Preparation's free exam preparation library. Each question includes the correct answer and a detailed explanation to help you understand the underlying concept, not just memorize the answer.

How to use this page: Read the question above, consider all four options (A through D), then check the highlighted correct answer and explanation. For active timed practice, start a free Everyday Science practice test or use flashcards for spaced repetition review.

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The p53 tumor suppressor gene is known as the guardian of the genome because it:

✓ Correct Answer: Option B

📚 About This Everyday Science Practice Question

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