The diagnostic criteria for sepsis include:

A) Fever alone

B) Suspected or documented infection with organ dysfunction as indicated by an acute increase in SOFA score of 2 or more

C) Elevated WBC only

D) Positive blood culture required

Explanation

Sepsis-3 (2016): life-threatening organ dysfunction caused by dysregulated host response to infection. SOFA score ≥2. qSOFA (screening): altered mentation, SBP≤100, RR≥22. Septic shock: vasopressors needed + lactate >2.

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